Performance in a technology-heavy world depends on the whole modpack, not one setting. The best approach is to make measured changes and test the same area after each change.
Start with render and simulation load
Reduce extreme render distance first and avoid loading more terrain than you need while troubleshooting. Large bases can combine rendering, entities, machines and chunk activity.
Review always-active systems
Factories that never stop can create unnecessary background work. Where your setup allows it, disable or gate production lines that are not currently needed.
Allocate sensible memory
More memory is not always better. Give a modded instance enough memory for the pack without starving the operating system or creating excessively long garbage-collection pauses.
Test mod changes one at a time
When performance drops after adding several mods, reproduce the issue in a copied instance and change one variable at a time. This makes conflicts much easier to identify.
Next step
Once your setup is stable, use the other guides on this site to plan power, wiring, performance and larger factory systems. For the file itself, use the main direct download section on the homepage.